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KMID : 0665220100230020135
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Korean Journal of Food and Nutrition
2010 Volume.23 No. 2 p.135 ~ p.140
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Effects of Water Extract Acorn on Mouse Immune Cell Activation Ex Vivo
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Ryu Hye-Sook
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Abstract
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Acorns have been used as a traditional remed as well as food source. However, few studies on their immunomodulating effects have been reported. In this study, the combined immunomodulative effect of a water extract of acorns was tested on seven to eight weeks old mice(balb/c). The mice were fed ad libitum on a chow diet, and a water extract of the plant mixture was orally administered every other day for four weeks at two different concentrations(50 and 500 ㎎/㎏ B.W.). The production of cytokine(IL-1β, IL-6, IL-2, IL-10, IFN-γ), secreted by macrophages stimulated with LPS or not, detected by ELISA assay using cytokine kit. After 48 h of incubation with mitogen(ConA or LPS) ex vivo study showed that cytokine (IL-1β, IL-6, IL-2, IL-10, IFN-γ) was detected in both of the 50 and 500 ㎎/㎏ B.W. supplementation groups with LPS stimulation. The results of this study may suggest that supplementation with acorn water extract increase immune function by regulating cytokine production capacity by activated macrophages.
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KEYWORD
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IL-1β, IL-6, IL-2, IL-10, IFN-γ
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